Enabling persistent connections (-pc+) is useful when network coverage is good and there is heavy message traffic over QAnywhere. In this scenario, you can reduce the network overhead of setting up and taking down a TCP/IP connection every time a message transmission occurs.
Disabling persistent connections (-pc-) is useful in the following scenarios when the client device has a public IP address and is reachable by UDP or SMS:
The client device is using dial-up networking and connection time charges are an issue.
There is light message traffic over QAnywhere. Persistent TCP/IP connections consume network server resources, and so could have an impact on scalability.
The client device network coverage is unreliable. You can use the automatic policy to transmit messages when connection is possible. Trying to maintain persistent connections in this environment is not useful and can waste CPU resources.