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Performance of SQL Anywhere is somewhat slower when the database is encrypted. The performance impact depends on how often pages are read from or written to disk, and can be minimized by ensuring that the server is using an adequate cache size.
You can increase the starting size of the cache with the -c option when you start the server. For operating systems that support dynamic resizing of the cache, the cache size that is used may be restricted by the amount of memory that is available; to increase the cache size, increase the available memory.