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The following are examples of changes that should not be made to a deployed and running SQL Remote setup. From the list, you will see that there is a class of changes that are permissive, and these are generally permissible, while other changes are restrictive, and must be avoided.
The following changes must be avoided, except under the conditions stated:
Change the publisher for the consolidated database.
Make restrictive changes to tables, such as dropping a column or altering a column to not allow NULL values. Changes that include the column or including NULL entries may already be being sent in messages around the SQL Remote setup, and will fail.
Alter a publication. Publication definitions must be maintained at both local and remote sites, and changes that rely on the old publication definition may already be being sent in messages around the SQL Remote setup.
You can make permissive changes, such as adding a new table or column, as long as you use passthrough to ensure that the new table or column exists in the remote database and in the publication at the remote database.
Drop a subscription. This can be done only if you use passthrough deletes to remove the data at the remote site.
Unload and reload a SQL Anywhere database.
If a SQL Anywhere database is participating in replication, it cannot be unloaded and reloaded without re-synchronizing the database. Replication is based on the transaction log, and when a database is unloaded and reloaded, the old transaction log is no longer available. For this reason, good backup practices are especially important when participating in replication.