You can drop a publication using either Sybase Central or the DROP PUBLICATION statement. If you drop a publication, all subscriptions to that publication are automatically deleted as well.
You must have DBA authority to drop a publication.
Connect to the database as a user with DBA authority.
Open the Publications folder.
Right-click the desired publication and choose Delete from the popup menu.
Connect to the database as a user with DBA authority.
Execute a DROP PUBLICATION statement.
The following statement drops the publication named PubOrders.
DROP PUBLICATION PubOrders