Fragmentation occurs as you make changes to your database, and performance can suffer if your files, tables, or indexes are excessively fragmented.
Reducing fragmentation becomes more important as your database increases in size.
If you are noticing a significant decrease in performance, consider:
rebuilding your database to reduce table and/or index fragmentation, especially if you have performed extensive delete/update/insert activity on multiple tables
putting the database on a disk partition by itself to reduce file fragmentation
running one of the available Windows utilities periodically to reduce file fragmentation
reorganizing your tables to reduce database fragmentation
using the REORGANIZE TABLE statement to defragment rows in a table, or to compress indexes which may have become sparse due to DELETEs. Reorganizing tables can reduce the total number of pages used to store a table and its indexes, and it may reduce the number of levels in an index tree as well.